Ribosomal protein S6 kinase, 70kDa, polypeptide 1 pseudogene[5] (RPS6KB1 pseudogene[5])

ENSG00000226521 encodes a **pseudogene** related to the protein-coding gene **RPS6KB1**, which encodes the protein *ribosomal protein S6 kinase beta-1* (S6K1, p70S6K)[5][1][9]. Pseudogenes are generally non-functional DNA sequences similar to functional genes but typically do not encode functional proteins. This particular pseudogene does **not produce an active kinase enzyme** or functional receptor, and is not considered a therapeutic target. The functional RPS6KB1 gene is involved in the mTOR signaling pathway, regulating protein synthesis and cell growth, but those functions are not attributed to the pseudogene[5][1][7][9]. As a pseudogene, ENSG00000226521 has **no established biological function, clinical relevance, or pharmacological interactions**. **Key clarifications:** - This entry is a **pseudogene**, not a functional receptor, enzyme, or other common therapeutic target class—hence it is not a drug target and provides no actionable biology or pharmacology[5]. - **is_incorrect = true** because this target is unlikely to be therapeutically relevant, and the entry may reflect a confusion between the pseudogene (ENSG00000226521) and the functional gene (RPS6KB1, ENSG00000108443)[5][9]. **Summary:** ENSG00000226521 refers to a pseudogene with homology to the functional kinase RPS6KB1, but lacks biological or clinical significance, therapeutic targeting potential, or associated drug interactions[5].

Other names

Ribosomal protein S6 kinase, 70kDa, polypeptide 1 pseudogeneRPS6KB1P